Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography.

ABSTRACT: Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality. Clinical anticoagulation practices are currently heterogeneous, reflecting physician preference. This study uses thrombelastography and hematology markers to evaluate whether clot formation and fibrinolysis are abnormal in pulmonary arterial hypertension patients. Venous blood was collected from healthy volunteers (n = 20) and patients with pulmonary arterial hypertension (n = 20) on stable medical therapy for thrombelastography analysis. Individual thrombelastography parameters and a calculated coagulation index were used for comp

SUBMITTER: Lu M 

PROVIDER: S-EPMC8237222 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature