Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes.

ABSTRACT:

Background

The International Agency for Research on Cancer (IARC) classifies diesel engine exhaust as carcinogenic to humans based on sufficient evidence for lung cancer. IARC noted, however, an increased risk of bladder cancer (based on limited evidence).

Objective

To evaluate the association between quantitative, lifetime occupational diesel exhaust exposure and risk of urothelial cell carcinoma of the bladder (UBC) overall and according to pathological subtypes.

Methods

Data from personal interviews with 1944 UBC cases, as well as formalin-fixed paraffin-embedded tumor tissue blocks, and 2135 controls were pooled from two case-control studies conducted in the U.S. and Spain. Lifetime occupational histories combined with exposure-oriented questions were used to esti

SUBMITTER: Koutros S 

PROVIDER: S-EPMC8237313 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature