Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression.

ABSTRACT:

Objective

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum ranging from hepatosteatosis to progressive nonalcoholic steatohepatitis that can lead to cirrhosis. Humans with low levels of prohormone thyroxine (T₄) have a higher incidence of NAFLD, and thyroid hormone treatment is very promising in all patients with NAFLD. Deiodinase type 1 (Dio1) is a hepatic enzyme that converts T₄ to the bioactive T₃ and therefore regulates thyroid hormone availability within hepatocytes. We investigated the role of this intrahepatic regulation during the progression of NAFLD.

Methods

We investigated hepatic thyroid hormone metabolism in two NAFLD models: wild-type mice fed a Western diet with fructose and Lepr^db mice fed a methionine-

SUBMITTER: Bruinstroop E 

PROVIDER: S-EPMC8237360 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature