Harmful mutation load in the mitochondrial genomes of cattle breeds.

ABSTRACT:

Objective

Domestication of wild animals results in a reduction in the effective population size, and this could affect the deleterious mutation load of domesticated breeds. Furthermore, artificial selection will also contribute to the accumulation of deleterious mutations due to the increased rate of inbreeding among these animals. The process of domestication, founder population size, and artificial selection differ between cattle breeds, which could lead to a variation in their deleterious mutation loads. We investigated this using mitochondrial genome data from 364 animals belonging to 18 cattle breeds of the world.

Results

Our analysis revealed more than a fivefold difference in the deleterious mutation load among cattle breeds. We also observed a negative correlation be

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC8237412 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature