Priming with intranasal lactobacilli prevents Pseudomonas aeruginosa acute pneumonia in mice.

ABSTRACT:

Background

Increasing resistance to antibiotics of Pseudomonas aeruginosa leads to therapeutic deadlock and alternative therapies are needed. We aimed to evaluate the effects of Lactobacillus clinical isolates in vivo, through intranasal administration on a murine model of Pseudomonas aeruginosa pneumonia.

Results

We screened in vitro 50 pulmonary clinical isolates of Lactobacillus for their ability to decrease the synthesis of two QS dependent-virulence factors (elastase and pyocyanin) produced by Pseudomonas aeruginosa strain PAO1. Two blends of three Lactobacillus isolates were then tested in vivo: one with highly effective anti-PAO1 virulence factors properties (blend named L.rff for L. rhamnosus, two L. fermentum strains), and the second with no properties (blend named

SUBMITTER: Fangous MS 

PROVIDER: S-EPMC8237558 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature