Ontology highlight
ABSTRACT:
SUBMITTER: Enjalbert R
PROVIDER: S-EPMC8237689 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Enjalbert Romain R Hardman David D Krüger Timm T Bernabeu Miguel O MO
Proceedings of the National Academy of Sciences of the United States of America 20210617 25
The tumor microenvironment is abnormal and associated with tumor tissue hypoxia, immunosuppression, and poor response to treatment. One important abnormality present in tumors is vessel compression. Vessel decompression has been shown to increase survival rates in animal models via enhanced and more homogeneous oxygenation. However, our knowledge of the biophysical mechanisms linking tumor decompression to improved tumor oxygenation is limited. In this study, we propose a computational model to ...[more]