The spinal distribution of metastatic renal cell carcinoma: Support for locoregional rather than arterial hematogenous mode of early bony dissemination.

ABSTRACT:

Background

Quantifying the degree to which spinal involvement of metastatic renal cell carcinoma (mRCC) is a locoregional phenomenon vs. a hematogenous, bone-specific affinity has implications for prognosis and antimetastatic therapy.

Objective

To investigate the distribution of spinal metastasis in mRCC and to explore relationships between clinical factors and patterns of spinal spread.

Methods

Patients with mRCC and spinal involvement from June 2005 to November 2018 were identified. Clinical and biologic features including primary tumor size and degree of spinal and nonbony metastatic involvement were collected. Spinal distributions were evaluated by the permutation test, with the null hypothesis that metastases are distributed uniformly across levels.

Results

SUBMITTER: Attalla K 

PROVIDER: S-EPMC8237695 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature