Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination.

ABSTRACT: The skin is an attractive tissue target for vaccination, as it is readily accessible and contains a dense population of antigen-presenting and immune-accessory cells. Microneedle arrays (MNAs) are emerging as an effective tool for in situ engineering of the cutaneous microenvironment to enable diverse immunization strategies. Here, we present novel dissolving undercut MNAs and demonstrate their application for effective multicomponent cutaneous vaccination. The MNAs are composed of micron-scale needles featuring pyramidal heads supported by undercut stem regions with filleted bases to ensure successful skin penetration and retention during application. Prior efforts to fabricate dissolving undercut microstructures were limited and required complex and lengthy processing and assembly steps.

SUBMITTER: Balmert SC 

PROVIDER: S-EPMC8237702 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature