Progression of Emphysema and Small Airways Disease in Cigarette Smokers.

ABSTRACT:

Background

Little is known about factors associated with emphysema progression in cigarette smokers. We evaluated factors associated with change in emphysema and forced expiratory volume in 1 second (FEV₁) in participants with and without chronic obstructive pulmonary disease (COPD).

Methods

This retrospective study included individuals participating in the COPD Genetic Epidemiology study who completed the 5-year follow-up, including inspiratory and expiratory computed tomography (CT) and spirometry. All paired CT scans were analyzed using micro-mapping, which classifies individual voxels as emphysema or functional small airway disease (fSAD). Presence and progression of emphysema and FEV₁ were determined based on comparison to nonsmoker values. Logisti

SUBMITTER: Pompe E 

PROVIDER: S-EPMC8237975 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature