CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells.

ABSTRACT: Mutations in CFTR alter macrophage responses, for example, by reducing their ability to phagocytose and kill bacteria. Altered macrophage responses may facilitate bacterial infection and inflammation in the lungs, contributing to morbidity and mortality in cystic fibrosis (CF). Extracellular vesicles (EVs) are secreted by multiple cell types in the lungs and participate in the host immune response to bacterial infection, but the effect of EVs secreted by CF airway epithelial cells (AEC) on CF macrophages is unknown. This report examines the effect of EVs secreted by primary AEC on monocyte-derived macrophages (MDM) and contrasts responses of CF and wild type (WT) MDM. We found that EVs generally increase pro-inflammatory cytokine secretion and expression of innate immune genes in MD

SUBMITTER: Koeppen K 

PROVIDER: S-EPMC8238154 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature