Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis.

ABSTRACT: Blood flow governs transport of oxygen and nutrients into tissues. Hypoxic tissues secrete VEGFs to promote angiogenesis during development and in tissue homeostasis. In contrast, tumors enhance pathologic angiogenesis during growth and metastasis, suggesting suppression of tumor angiogenesis could limit tumor growth. In line with these observations, various factors have been identified to control vessel formation in the last decades. However, their impacts on the vascular transport properties of oxygen remain elusive. Here, we take a computational approach to examine the effects of vascular branching on blood flow in the growing vasculature. First of all, we reconstruct a 3D vascular model from the 2D confocal images of the growing vasculature at postnatal day 5 (P5) mouse retina, then si

SUBMITTER: Mirzapour-Shafiyi F 

PROVIDER: S-EPMC8238234 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature