Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells.

ABSTRACT:

Background

Resistance to antiproliferative chemotherapies remains a significant challenge in the care of patients with solid tumors. Glucocorticoids, including endogenous cortisol, have been shown to induce pro-survival pathways in epithelial tumor cells. While pro-apoptotic effects of glucocorticoid receptor (GR) antagonism have been demonstrated under select conditions, the breadth and nature of these effects have not been fully established.

Materials and methods

To guide studies in cancer patients, relacorilant, an investigational selective GR modulator (SGRM) that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

Results

In the MIA PaCa-2 c

SUBMITTER: Greenstein AE 

PROVIDER: S-EPMC8238250 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature