Lever-press duration as a measure of frustration in sucrose and drug reinforcement.

ABSTRACT:

Rationale

Currently there is little research into the role of frustration in substance use disorders despite research showing that frustration tolerance in humans is associated with a lower likelihood of developing substance use problems, better outcomes in recovery, and fewer relapses.

Objective

In order to address this need, our studies use a rat model to focus on frustration-related behavior in natural reward and addiction-related behavioral procedures. Frustration is defined as when a subject is unable to achieve a reinforcer, receives less of a reinforcer than anticipated, or has to work harder to achieve a reinforcer.

Results

In these studies, bar-press durations increase when rats are in a state of frustration during self-administration of sucrose, fentanyl, or

SUBMITTER: Vasquez TES 

PROVIDER: S-EPMC8238410 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature