TLR2 Regulates Mast Cell IL-6 and IL-13 Production During Listeria monocytogenes Infection.

ABSTRACT: Listeria monocytogenes (L.m) is efficiently controlled by several cells of the innate immunity, including the Mast Cell (MC). MC is activated by L.m inducing its degranulation, cytokine production and microbicidal mechanisms. TLR2 is required for the optimal control of L.m infection by different cells of the immune system. However, little is known about the MC receptors involved in recognizing this bacterium and whether these interactions mediate MC activation. In this study, we analyzed whether TLR2 is involved in mediating different MC activation responses during L.m infection. We found that despite MC were infected with L.m, they were able to clear the bacterial load. In addition, MC degranulated and produced ROS, TNF-α, IL-1β, IL-6, IL-13 and MCP-1 in response to bacterial infec

SUBMITTER: Soria-Castro R 

PROVIDER: S-EPMC8238461 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature