Shift work, low-grade inflammation, and chronic pain: a 7-year prospective study.

ABSTRACT:

Objectives

We investigated prospective associations of shift work with chronic pain and C-reactive protein (CRP), an indicator of inflammation. Furthermore, we elucidated CRP as a possible mediator and/or moderator of effects of shift work on pain.

Methods

Data from a 7 years follow-up study were analyzed (N = 2323). Shift work and chronic pain of "neck/shoulder", "arm/hand", "upper back", "low back", "hip/leg/feet", and "other regions" were measured by questionnaires. "Chronic widespread pain", "number of chronic pain sites", and "any chronic pain" were computed. CRP was measured in serum samples. Logistic and Poisson regressions were conducted. Mediation was assessed by casual mediation analyses and moderation by the Relative Excess Risk due to Interaction (RERI).

Resul

SUBMITTER: Christensen JO 

PROVIDER: S-EPMC8238752 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature