Circulating Lymphocyte Counts Early During Radiation Therapy Are Associated With Recurrence in Pediatric Medulloblastoma.

ABSTRACT:

Purpose

Decreased peripheral lymphocyte counts are associated with survival after radiation therapy (RT) in several solid tumors, although they appear late during or after the radiation course and often correlate with other clinical factors. Here we investigate if absolute lymphocyte counts (ALCs) are independently associated with recurrence in pediatric medulloblastoma early during RT.

Methods and materials

We assessed 202 patients with medulloblastoma treated between 2000 and 2016 and analyzed ALC throughout therapy, focusing on both early markers (ALC during week 1 - ALC_wk1; grade 3+ Lymphopenia during week 2 - Lymphopenia_wk2) and late markers (ALC nadir). Uni- and multivariable regressions were used to assess association of clinical and treatment va

SUBMITTER: Grassberger C 

PROVIDER: S-EPMC8238781 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature