Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.

ABSTRACT:

Background & aims

Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the key enzyme to generate PAPS, which is the universal sulfonate donor for all sulfation reactions. The goal of this study was to determine whether and how PAPSS2 plays a role in colitis and colonic carcinogenesis.

Methods

Tissue arrays of human colon cancer specimens, gene expression data, and clinical features of cancer patients were analyzed. Intestinal-specific Papss2 knockout mice (Papss2^ΔIE) were created and subjected to dextran sodium sulfate-induced colitis and colonic carcinogenesis induced by a combined treatment of azoxymethane and dextran sodium sulfate or az

SUBMITTER: Xu P 

PROVIDER: S-EPMC8238844 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature