Biomarkers of Immune Activation and Incident Kidney Failure With Replacement Therapy: Findings From the African American Study of Kidney Disease and Hypertension.

ABSTRACT:

Rationale & objective

Immune activation is fundamental to the pathogenesis of many kidney diseases. Innate immune molecules such as soluble urokinase-type plasminogen activator receptor (suPAR) have been linked to the incidence and progression of chronic kidney disease (CKD). Whether other biomarkers of immune activation are associated with incident kidney failure with replacement therapy (KFRT) in African Americans with nondiabetic kidney disease is unclear.

Study design

Prospective cohort.

Setting & participants

African American Study of Kidney Disease and Hypertension (AASK) participants with available baseline serum samples for biomarker measurement.

Predictors

Baseline serum levels of soluble tumor necrosis factor receptor 1 (sTNFR1), sTNFR2, tumor necrosi

SUBMITTER: Chen TK 

PROVIDER: S-EPMC8238859 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature