Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.

ABSTRACT: Genome-wide association studies (GWASs) have identified hundreds of genetic loci for osteoporosis (OP) and rheumatoid arthritis (RA), individually, however, a large proportion of the total trait heritability remains unexplained. Previous studies demonstrated that these two diseases may share some common genetic determination and risk factors, but they were generally focused on individual trait and failed to identify the common variants that play key functional roles in the etiology of these two diseases. Here, we performed a conditional false discovery rate (cFDR) analysis to identify novel pleiotropic variants shared between them by integrating two independent GWASs with summary statistics for total body bone mineral density (TB-BMD, a major risk factor for osteoporosis) (n = 66,628) and

SUBMITTER: Liu YQ 

PROVIDER: S-EPMC8238865 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature