Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.

ABSTRACT:

Background

Carboxypeptidase G₂ (CPDG₂ ; glucarpidase) is a rescue drug for patients at risk for kidney injury from high-dose methotrexate (MTX). As there are no strategies for predicting patients who will require CDPG₂ , we evaluated the role of demographic, clinical, and genetic factors for CPDG₂ use.

Procedure

Cases who received CPDG₂ and controls who did not were identified by chart review of acute lymphoblastic leukemia (ALL) patients who received MTX doses between 1000 and 5000 mg/m² between 2010 and 2017. We used multivariable Bayesian logistic regression to evaluate the association of CPDG₂ use with demographic and clinical variables and, on a subset of patients, with genetic ancestry and 49

SUBMITTER: Zobeck MC 

PROVIDER: S-EPMC8238882 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature