Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC8238901 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Zhang Qi Q Ma Duo D Wu Fuqing F Standage-Beier Kylie K Chen Xingwen X Wu Kaiyue K Green Alexander A AA Wang Xiao X
Nature chemical biology 20210621 7
The ability to tune RNA and gene expression dynamics is greatly needed for biotechnological applications. Native RNA stabilizers or engineered 5' stability hairpins have been used to regulate transcript half-life to control recombinant protein expression. However, these methods have been mostly ad hoc and hence lack predictability and modularity. Here, we report a library of RNA modules called degradation-tuning RNAs (dtRNAs) that can increase or decrease transcript stability in vivo and in vitr ...[more]