Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

ABSTRACT:

Background

Pancreatic adenocarcinoma (PAAD) a highly lethal malignancy. The current use of clinical parameters may not accurately predict the clinical outcome, which further renders the unsatisfactory therapeutic outcome.

Methods

In this study, we retrospectively analyzed the clinical-pathological characteristics and prognosis of 253 PAAD patients. Univariate, multivariate, and Kaplan-Meier survival analyses were conducted to assess risk factors and clinical outcomes. For functional study, we performed bidirectional genetic manipulation of lactate dehydrogenase A (LDHA) in PAAD cell lines to measure PAAD progression by both in vitro and in vivo assays.

Results

LDHA is particularly overexpressed in PAAD tissues and elevated serum LDHA-transcribed isoenzymes-5 (LDH-5) w

SUBMITTER: Cheng CS 

PROVIDER: S-EPMC8238920 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature