Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.

ABSTRACT: The severity of tissue injury in burn wounds from associated inflammatory and immune sequelae presents a significant clinical management challenge. Among various biophysical wound management approaches, low dose biophotonics treatments, termed Photobiomodulation (PBM) therapy, has gained recent attention. One of the PBM molecular mechanisms of PBM treatments involves photoactivation of latent TGF-β1 that is capable of promoting tissue healing and regeneration. This work examined the efficacy of PBM treatments in a full-thickness burn wound healing in C57BL/6 mice. We first optimized the PBM protocol by monitoring tissue surface temperature and histology. We noted this dynamic irradiance surface temperature-monitored PBM protocol improved burn wound healing in mice with elevated TGF-β signa

SUBMITTER: Khan I 

PROVIDER: S-EPMC8238984 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature