Weakening of resistance force by cell-ECM interactions regulate cell migration directionality and pattern formation.

ABSTRACT: Collective migration of epithelial cells is a fundamental process in multicellular pattern formation. As they expand their territory, cells are exposed to various physical forces generated by cell-cell interactions and the surrounding microenvironment. While the physical stress applied by neighbouring cells has been well studied, little is known about how the niches that surround cells are spatio-temporally remodelled to regulate collective cell migration and pattern formation. Here, we analysed how the spatio-temporally remodelled extracellular matrix (ECM) alters the resistance force exerted on cells so that the cells can expand their territory. Multiple microfabrication techniques, optical tweezers, as well as mathematical models were employed to prove the simultaneous construction and

SUBMITTER: Hagiwara M 

PROVIDER: S-EPMC8239002 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature