Emergence of local and global synaptic organization on cortical dendrites.

ABSTRACT: Synaptic inputs on cortical dendrites are organized with remarkable subcellular precision at the micron level. This organization emerges during early postnatal development through patterned spontaneous activity and manifests both locally where nearby synapses are significantly correlated, and globally with distance to the soma. We propose a biophysically motivated synaptic plasticity model to dissect the mechanistic origins of this organization during development and elucidate synaptic clustering of different stimulus features in the adult. Our model captures local clustering of orientation in ferret and receptive field overlap in mouse visual cortex based on the receptive field diameter and the cortical magnification of visual space. Including action potential back-propagation explains br

SUBMITTER: Kirchner JH 

PROVIDER: S-EPMC8239006 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature