Age-Related Alterations in DTI Metrics in the Human Brain-Consequences for Age Correction.

ABSTRACT: Background: Over the life span, the diffusion metrics in brain MRI show different, partly nonlinear changes. These age-dependent changes also seem to exhibit regional differences with respect to the brain anatomy. The age correction of a study cohort's diffusion metrics might thus require consideration of age-related factors. Methods: Diffusion tensor imaging data sets were acquired from 219 healthy participants at ages between 19 and 81 years. Fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivity (AD and RD, respectively) maps were analyzed by a tract of interest-based fiber tracking approach. To describe diffusion metrics as a function of the participant age, linear splines were used to perform curve fitting in 21 specific tract systems coverin

SUBMITTER: Behler A 

PROVIDER: S-EPMC8239142 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature