Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts.

ABSTRACT: In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However, such methods report voxel-wise estimates, which vary from voxel-to-voxel for the same white matter bundle due to partial volume contributions from other pathways having different microstructure properties. Here, we propose a novel microstructure-informed tractography approach, COMMIT_AxSize, to resolve axon diameter index estimates at the streamline level, thus making the estimates invariant along trajectories. Compared to previously proposed voxel-wise methods, our formulation allows the estimation of a distinct axon d

SUBMITTER: Barakovic M 

PROVIDER: S-EPMC8239216 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature