Ontology highlight
ABSTRACT:
SUBMITTER: Wesseling M
PROVIDER: S-EPMC8239225 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Wesseling Marian M Mulder Eva E Brans Maike A D MAD Kapteijn Daniek M C DMC Bulthuis Marian M Pasterkamp Gerard G Verhaar Marianne C MC Danser A H Jan AHJ van Goor Harry H Joles Jaap A JA de Jager Saskia C A SCA
Frontiers in pharmacology 20210615
Cardiorenal syndrome type 2 is characterized by kidney failure as a consequence of heart failure that affects >50% of heart failure patients. Murine transverse aortic constriction (TAC) is a heart failure model, where pressure overload is induced on the heart without any systemic hypertension or its consequences. Whether renal function is altered in this model is debated, and if so, at which time post-TAC renal dysfunction starts to contribute to worsening of cardiac function. We therefore studi ...[more]