Oleate Prevents Palmitate-Induced Mitochondrial Dysfunction in Chondrocytes.

ABSTRACT: The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors related to metabolic disorders that are involved in the metabolic phenotype of OA. The aim of this work is study the effects of palmitate and oleate on cellular metabolism in an "in vitro" model of human chondrocytes. The TC28a2 chondrocyte cell line was used to analyze the effect of palmitate and oleate on mitochondrial and glycolytic function, Adenosine triphosphate (ATP) production and lipid droplets accumulation. Palmitate, but not oleate, produces mitochondrial dysfunction observed with a lower coupling efficiency, maximal respiration and spare respiratory capacity. Glyc

SUBMITTER: Vazquez-Mosquera ME 

PROVIDER: S-EPMC8239231 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature