Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies.

ABSTRACT: In the search for novel, metal-based drug complexes that may be of value as anticancer agents, five new transition metal complexes of sulfaclozine (SCZ) with Cu(II), Co(II), Ni(II), Zn(II), and Fe(II) were successfully synthesized. The chemical structure of each complex was characterized using elemental analysis (CHN), IR spectroscopy, UV-Vis spectroscopy, thermogravimetric analysis (TGA), and electronic paramagnetic resonance (EPR) spectroscopy. IR spectra indicated that the donor atoms were one sulfonyl oxygen atom and one pyrazine nitrogen atom, which associated with the metal ions to form a stable hexagonal coordination ring. The metal-ligand stability constant (K_f) revealed that Cu(II) and Ni(II) have good coordination stability among the metal compounds. Theoretical studie

SUBMITTER: Sharfalddin AA 

PROVIDER: S-EPMC8239243 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature