Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish.

ABSTRACT: Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it is necessary to recognize the interactions of molecules, pathways, and biological processes within these networks. The developing brain is a prime example of an extremely complex network, which makes developmental neurotoxicity one of the most challenging areas in toxicology. We have developed a systems toxicology method that uses a computable biological network to represent molecular interactions in the developing brain of zebrafish larvae. The network is curated from scientific literature and describes interactions between biological pro

SUBMITTER: Li RA 

PROVIDER: S-EPMC8239408 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature