Bioinformatic Analyses Identify a Prognostic Autophagy-Related Long Non-coding RNA Signature Associated With Immune Microenvironment in Diffuse Gliomas.

ABSTRACT:

Background

Autophagy and long non-coding RNA (lncRNA) play a critical role in tumor progression and microenvironment. However, the role of autophagy-related lncRNAs (ARLs) in glioma microenvironment remains unclear.

Methods

A total of 988 diffuse glioma samples were extracted from TCGA and CGGA databases. Consensus clustering was applied to reveal different subgroups of diffuse gliomas. Kaplan-Meier analysis was used to evaluate survival differences between groups. The infiltration of immune cells was estimated by ssGSEA, TIMER, and CIBERSORT algorithms. The construction of ARL signature was conducted using principal component analysis.

Results

Consensus clustering revealed two clusters of diffuse gliomas, in which cluster 1 was associated with poor prognosis and enri

SUBMITTER: Xu S 

PROVIDER: S-EPMC8239411 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature