Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass.

ABSTRACT:

Objective

Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the lifetime. β cells are formed from progenitors during embryonic development but undergo significant expansion in quantity and attain functional maturity after birth. The signals and pathways involved in these processes are not fully elucidated. Cyclic adenosine monophosphate (cAMP) is an intracellular signaling molecule that is known to regulate insulin secretion, gene expression, proliferation, and survival of adult β cells. The heterotrimeric G protein Gs stimulates the cAMP-dependent pathway by activating adenylyl cyclase. In this study, we sought to explore the role of Gs-dependent signaling in postnatal β-cell develo

SUBMITTER: Serra-Navarro B 

PROVIDER: S-EPMC8239471 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature