Leri: A web-server for identifying protein functional networks from evolutionary couplings.

ABSTRACT: Information on the co-evolution of amino acid pairs in a protein can be used for endeavors such as protein engineering, mutation design, and structure prediction. Here we report a method that captures significant determinants of proteins using estimated co-evolution information to identify networks of residues, termed "residue communities", relevant to protein function. On the benchmark dataset (67 proteins with both catalytic and allosteric residues), the Pearson's correlation between the identified residues in the communities at functional sites is 0.53, and it is higher than 0.8 by taking account of conserved residues derived from the method. On the endoplasmic reticulum-mitochondria encounter structure complex, the results indicate three distinguishable residue communities that are rel

SUBMITTER: Cheung NJ 

PROVIDER: S-EPMC8239741 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature