Hypertension and Hypercholesterolemia Modify Dementia Risk in Relation to APOEɛ4 Status.

ABSTRACT:

Background

There is significant interest in understanding the role of modifiable vascular risk factors contributing to dementia risk across age groups.

Objective

Risk of dementia onset was assessed in relation to vascular risk factors of hypertension and hypercholesterolemia among cognitively normal APOEɛ4 carriers and non-carriers.

Methods

In a sample of prospectively characterized longitudinal cohort from the National Alzheimer's Coordinating Center database, 9,349 participants met criteria for normal cognition at baseline, had a CDR-Global (CDR-G) score of zero, and had concomitant data on APOEɛ4 status and medical co-morbidities including histories of hypertension and hypercholesterolemia. Multivariable Cox proportional hazards models adjusted for well-known poten

SUBMITTER: Pillai JA 

PROVIDER: S-EPMC8239808 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature