Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers: A ³¹ P MRS study at 7T.

ABSTRACT:

Purpose

Phosphorus spectroscopy (³¹ P-MRS) is a proven method to probe cardiac energetics. Studies typically report the phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio. We focus on another ³¹ P signal: inorganic phosphate (Pi), whose chemical shift allows computation of myocardial pH, with Pi/PCr providing additional insight into cardiac energetics. Pi is often obscured by signals from blood 2,3-diphosphoglycerate (2,3-DPG). We introduce a method to quantify Pi in 14 min without hindrance from 2,3-DPG.

Methods

Using a ³¹ P stimulated echo acquisition mode (STEAM) sequence at 7 Tesla that inherently suppresses signal from 2,3-DPG, the Pi peak was cleanly resolved. Resting state UTE-chemical shift imaging (PCr/ATP) and STEAM ³¹

SUBMITTER: Apps A 

PROVIDER: S-EPMC8239988 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature