Fibroblast growth factor 13 stabilizes microtubules to promote Na⁺ channel function in nociceptive DRG neurons and modulates inflammatory pain.

ABSTRACT:

Introduction

Fibroblast growth factor homologous factors (FHFs), among other fibroblast growth factors, are increasingly found to be important regulators of ion channel functions. Although FHFs have been link to several neuronal diseases and arrhythmia, its role in inflammatory pain still remains unclear.

Objectives

This study aimed to investigate the role and mechanism of FGF13 in inflammatory pain.

Methods

Fgf13 conditional knockout mice were generated and CFA-induced chronic inflammatory pain model was established to measure the pain threshold. Immunostaining, western blot and quantitative real-time reverse transcription PCR (qRT-PCR) were performed to detect the expression of FGF13 in CFA-induced inflammatory pain. Whole-cell patch clamp recording was used

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8240113 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature