Evolution of mouse circadian enhancers from transposable elements.

ABSTRACT:

Background

Transposable elements are increasingly recognized as a source of cis-regulatory variation. Previous studies have revealed that transposons are often bound by transcription factors and some have been co-opted into functional enhancers regulating host gene expression. However, the process by which transposons mature into complex regulatory elements, like enhancers, remains poorly understood. To investigate this process, we examined the contribution of transposons to the cis-regulatory network controlling circadian gene expression in the mouse liver, a well-characterized network serving an important physiological function.

Results

ChIP-seq analyses reveal that transposons and other repeats contribute ~ 14% of the binding sites for core circadian regulators (CRs) incl

SUBMITTER: Judd J 

PROVIDER: S-EPMC8240256 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature