Effect of cachexia on bone turnover in cancer patients: a case-control study.

ABSTRACT:

Background

Increased bone turnover is frequently observed in advanced cancer and predominantly related to bone metastases or therapy. Cachexia represents an important cause of morbidity and mortality in cancer patients. Key features are weight loss, muscle wasting and chronic inflammation, which induce profound metabolic changes in several organs, including the bone. However, whether cachexia contributes to abnormal bone metabolism in cancer patients is unknown. Aim of the present study was to determine the potential correlation of bone turnover markers with body composition and laboratory parameters in treatment-naïve cancer patients.

Methods

In this cross-sectional study we measured the levels of carboxy terminal telopeptide of collagen (CTX), an indicator of bone resorpti

SUBMITTER: Zwickl H 

PROVIDER: S-EPMC8240310 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature