MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children.

ABSTRACT:

Background

Midregional-proadrenomedullin (MR-proADM) is a useful prognostic peptide in severe infectious pathologies in the adult population. However, there are no studies that analyze its utility in febrile urinary tract infection (fUTI) in children. An accurate biomarker would provide an early detection of patients with kidney damage, avoiding other invasive tests like renal scintigraphy scans. Our objective is to study the usefulness of MR-proADM as a biomarker of acute and chronic renal parenchymal damage in fUTI within the pediatric population.

Methods

A prospective cohort study was conducted in pediatric patients with fUTI between January 2015 and December 2018. Plasma and urine MR-proADM levels were measured at admission in addition to other laboratory parameters. Aft

SUBMITTER: Penalver Penedo R 

PROVIDER: S-EPMC8240321 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature