ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12.

ABSTRACT:

Background

Zika virus (ZIKV) infection and ZIKV epidemic have been continuously spreading silently throughout the world and its associated microcephaly and other serious congenital neurological complications poses a significant global threat to public health. Type I interferon response to ZIKV infection in host cells suppresses viral replication by inducing the expression of interferon-stimulated genes (ISGs).

Methods

The study aims to demonstrate the anti-ZIKV mechanism of PARP11. PARP11 knock out and overexpressing A549 cell lines were constructed to evaluate the anti-ZIKV function of PARP11. PARP11^-/-, PARP12^-/- and PARP11^-/-PARP12^-/- HEK293T cell lines were constructed to explain the synergistic effect of PARP11 and PARP12 on N

SUBMITTER: Li L 

PROVIDER: S-EPMC8240438 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature