Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin

ABSTRACT: Objectives This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To estimate the diagnostic accuracy of Xpert MTB/XDR for the detection of pulmonary tuberculosis in people with signs and symptoms of pulmonary tuberculosis. To estimate the diagnostic accuracy of Xpert MTB/XDR for resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin in people irrespective of rifampicin resistance and people with detected rifampicin resistance. In these populations, pulmonary tuberculosis will have been detected by Xpert MTB/XDR (as it is a reflex test). Such populations typically will have received prior testing verifying tuberculosis with another WHO‐approved test.

Secondary objectives

To compare the diagnostic accuracy of Xpert MTB/XDR by direct test

SUBMITTER: Pillay S 

PROVIDER: S-EPMC8240501 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature