The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial.

ABSTRACT:

Background

Vitamin D supplementation may prevent falls in older persons, but evidence is inconsistent, possibly because of dosage differences.

Objective

To compare the effects of 4 doses of vitamin D₃ supplements on falls.

Design

2-stage Bayesian, response-adaptive, randomized trial. (ClinicalTrials.gov: NCT02166333).

Setting

2 community-based research units.

Participants

688 participants, aged 70 years and older, with elevated fall risk and a serum 25-hydroxyvitamin D [25-(OH)D] level of 25 to 72.5 nmol/L.

Intervention

200 (control), 1000, 2000, or 4000 IU of vitamin D₃ per day. During the dose-finding stage, participants were randomly assigned to 1 of the 4 vitamin D₃ doses, and the best noncontrol dose for preve

SUBMITTER: Appel LJ 

PROVIDER: S-EPMC8240534 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature