Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice.

ABSTRACT:

Background

Delayed wound healing remains a common but challenging problem in patients with acute or chronic wound following accidental scald burn injury. However, the systematic and detailed evaluation of the scald burn injury, including second-degree deep scald (SDDS) and third-degree scald (TDS), is still unclear. The present study aims to analyze the wound-healing speed, the formation of granulation tissue, and the healing quality after cutaneous damage.

Methods

In order to assess SDDS and TDS, the models of SDDS and TDS were established using a scald instrument in C57BL/6 mice. Furthermore, an excisional wound was administered on the dorsal surface in mice (Cut group). The wound-healing rate was first analyzed at days 0, 3, 5, 7, 15 and 27, with the Cut group as a contro

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8240558 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature