Polysomal mRNA Association and Gene Expression in Trypanosoma brucei.

ABSTRACT: Background: The contrasting physiological environments of  Trypanosoma brucei procyclic (insect vector) and bloodstream (mammalian host) forms necessitates deployment of different molecular processes and, therefore, changes in protein expression. Transcriptional regulation is unusual in  T. brucei because the arrangement of genes is polycistronic; however, genes which are transcribed together are subsequently cleaved into separate mRNAs by  trans-splicing. Following pre-mRNA processing, the regulation of mature mRNA stability is a tightly controlled cellular process. While many stage-specific transcripts have been identified, previous studies using RNA-seq suggest that changes in overall transcript level do not necessarily reflect the abundance of the correspond

SUBMITTER: Tinti M 

PROVIDER: S-EPMC8240603 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature