Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging.

ABSTRACT: Magnetic resonance (MR)/optical dual-mode imaging with high sensitivity and high tissue resolution have attracted many attentions in biomedical applications. To avert aggregation-caused quenching of conventional fluorescence chromophores, an aggregation-induced emission molecule tetraphenylethylene (TPE)-conjugated amphiphilic polyethylenimine (PEI) covered superparamagnetic iron oxide (Alkyl-PEI-LAC-TPE/SPIO nanocomposites) was prepared as an MR/optical dual-mode probe. Alkyl-PEI-LAC-TPE/SPIO nanocomposites exhibited good fluorescence property and presented higher T ₂ relaxivity (352 Fe mM^-1s^-1) than a commercial contrast agent Feridex (120 Fe mM^-1s^-1) at 1.5 T. The alkylation degree of Alkyl-PEI-LAC-TPE effects the restriction

SUBMITTER: Yang L 

PROVIDER: S-EPMC8240647 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature