White Blood Cell and Platelet Dynamics Define Human Inflammatory Recovery.

ABSTRACT: Inflammation is the physiologic reaction to cellular and tissue damage caused by pathologic processes including trauma, infection, and ischemia ¹ . Effective inflammatory responses integrate molecular and cellular functions to prevent further tissue damage, initiate repair, and restore homeostasis, while futile or dysfunctional responses allow escalating injury, delay recovery, and may hasten death ² . Elevation of white blood cell count (WBC) and altered levels of other acute phase reactants are cardinal signs of inflammation, but the dynamics of these changes and their resolution are not established ^3,4 . Patient responses appear to vary dramatically with no clearly defined signs of good prognosis, leaving physicians reliant on qualitative interpretations

SUBMITTER: Foy BH 

PROVIDER: S-EPMC8240689 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature