Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease.

ABSTRACT: Alzheimer's disease is the most common form of dementia, characterized by a persistent and progressive impairment of cognitive functions. Alzheimer's disease is typically associated with extracellular deposits of amyloid-β peptide and accumulation of abnormally phosphorylated tau protein inside neurons (amyloid-β and neurofibrillary pathologies). It has been proposed that these pathologies cause neuronal degeneration and synaptic alterations, which are thought to constitute the major neurobiological basis of cognitive dysfunction in Alzheimer's disease. The hippocampal formation is especially vulnerable in the early stages of Alzheimer's disease. However, the vast majority of electron microscopy studies have been performed in animal models. In the present study, we performed an extensive 3

SUBMITTER: Montero-Crespo M 

PROVIDER: S-EPMC8240746 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature