The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions.

ABSTRACT: One of the complexities of understanding the pathology of familial forms of cardiac diseases is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere that are spatially explicit offer an approach to study aspects of mutational incorporation into myofilaments that are more challenging to get at experimentally. We studied two well characterized mutations of cardiac TnC, L48Q and I61Q, that decrease or increase the release rate of Ca²⁺ from cTnC, k_-Ca, resulting in HCM and DCM respectively [1]. Expression of these mutations in transgenic mice was used to provide experimental data for incorporation of 30 and 50% (respectively) into sarcomeres. Here we demonstrate that fixed length twitch contractions of trabeculae from mice containing mu

SUBMITTER: Mijailovich SM 

PROVIDER: S-EPMC8240760 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature