The Effectiveness of the Two-Dose BNT162b2 Vaccine: Analysis of Real-World Data.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were shown to be highly efficacious in preventing the disease in randomized controlled trials; nonetheless, evidence on the real-world effectiveness of this vaccine is limited. Study objective was to evaluate the effectiveness of BNT162b2 vaccine in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19-related hospitalization and mortality.

Methods

This historical cohort study included members of a large health provider in Israel that were vaccinated with at least 1 dose of BNT162b2. The primary outcome was incidence rate of a SARS-CoV-2 infection confirmed with real-time polymerase chain reaction (rt-PCR), between 7 and 27 days after second dose (protection-

SUBMITTER: Chodick G 

PROVIDER: S-EPMC8240867 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature